InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERCC5

Summary

InnateDB Protein

IDBP-812126.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC5

Protein Name

excision repair cross-complementation group 5

Synonyms

COFS3; ERCC5-201; ERCM2; UVDR; XPG; XPGC;

Species

Homo sapiens

Ensembl Protein

ENSP00000478667

InnateDB Gene

IDBG-49163 (ERCC5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity

Biological Process

GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001044 XPG/Rad2 endonuclease, eukaryotes
IPR006085 XPG N-terminal
IPR006086 XPG-I domain
IPR020045 5\'-3\' exonuclease, C-terminal domain
IPR029060 PIN domain-like

PFAM

PF00752
PF00867
PF01367
PF09293

PRINTS

PR00066

PIRSF

SMART

SM00485
SM00484

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

2073

UniGene

RefSeq

HUGO

HGNC:3437

OMIM

133530

CCDS

HPRD

IMGT

EMBL

GenPept