Version 5.4
Homo sapiens Protein: TNFRSF9
Summary
InnateDB Protein IDBP-812160.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF9
Protein Name tumor necrosis factor receptor superfamily, member 9
Synonyms 4-1BB; CD137; CDw137; ILA;
Species Homo sapiens
Ensembl Protein ENSP00000478699
InnateDB Gene IDBG-88268 (TNFRSF9)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0019955 cytokine binding
Biological Process
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0042127 regulation of cell proliferation
GO:0070207 protein homotrimerization
GO:2001180 negative regulation of interleukin-10 secretion
GO:2001183 negative regulation of interleukin-12 secretion
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001368 TNFR/NGFR cysteine-rich region
IPR020413 Tumour necrosis factor receptor 9
PFAM PF00020
PRINTS PR01924
PIRSF
SMART SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 3604
UniGene
RefSeq NP_001552
HUGO HGNC:11924
OMIM 602250
CCDS CCDS92
HPRD
IMGT
EMBL AL009183 AY438976 BC006196 L12964 U03397
GenPept AAA53133 AAA62478 AAH06196 AAR05440 CAB57398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca