InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOS1

Summary

InnateDB Protein

IDBP-812180.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOS1

Protein Name

nitric oxide synthase 1 (neuronal)

Synonyms

bNOS; IHPS1; N-NOS; NC-NOS; nNOS; NOS;

Species

Homo sapiens

Ensembl Protein

ENSP00000477999

InnateDB Gene

IDBG-59491 (NOS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004517	nitric-oxide synthase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0006809	nitric oxide biosynthetic process
GO:0006941	striated muscle contraction
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0042738	exogenous drug catabolic process
GO:0043267	negative regulation of potassium ion transport
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051346	negative regulation of hydrolase activity
GO:0051926	negative regulation of calcium ion transport
GO:0055114	oxidation-reduction process

Cellular Component

GO:0045121	membrane raft
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001478 PDZ domain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR004030 Nitric oxide synthase, N-terminal
IPR008254 Flavodoxin/nitric oxide synthase
IPR012144 Nitric-oxide synthase, eukaryote
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00595
PF13180
PF00667
PF02898
PF00258

PRINTS

PR00369
PR00371

PIRSF

PIRSF000333

SMART

SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References