InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTBP3

Summary

InnateDB Protein

IDBP-81249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTBP3

Protein Name

ROD1 regulator of differentiation 1 (S. pombe)

Synonyms

ROD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363375

InnateDB Gene

IDBG-81247 (PTBP3)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269PubMed:10207106, ECO:0000269PubMed:18335065, ECO:0000269PubMed:19441079, ECO:0000269PubMed:20937273}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in several hematopoietic cell lines examined. {ECO:0000269PubMed:10207106}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0009653	anatomical structure morphogenesis
GO:0033119	negative regulation of RNA splicing
GO:0043249	erythrocyte maturation