Version 5.4
Homo sapiens Protein: PTBP3
Summary
InnateDB Protein IDBP-81257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTBP3
Protein Name ROD1 regulator of differentiation 1 (S. pombe)
Synonyms ROD1;
Species Homo sapiens
Ensembl Protein ENSP00000210227
InnateDB Gene IDBG-81247 (PTBP3)
Protein Structure
UniProt Annotation
Function RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269PubMed:10207106, ECO:0000269PubMed:18335065, ECO:0000269PubMed:19441079, ECO:0000269PubMed:20937273}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in several hematopoietic cell lines examined. {ECO:0000269PubMed:10207106}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-O95758
TrEMBL X6R242
UniProt Splice Variant
Entrez Gene 9991
UniGene Hs.621703
RefSeq
HUGO HGNC:10253
OMIM 607527
CCDS
HPRD 09603
IMGT
EMBL AL158824 AL359073
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca