Homo sapiens Protein: MTHFD1L
Summary
InnateDB Protein IDBP-812606.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTHFD1L
Protein Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms dJ292B18.2; FTHFSDC1; MTC1THFS;
Species Homo sapiens
Ensembl Protein ENSP00000479539
InnateDB Gene IDBG-97919 (MTHFD1L)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000559 Formate-tetrahydrofolate ligase, FTHFS
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01268
PF00763
PF02882
PRINTS PR00085
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5JYA8
UniProt Splice Variant
Entrez Gene 25902
UniGene
RefSeq NP_001229697
HUGO HGNC:21055
OMIM 611427
CCDS CCDS75536
HPRD
IMGT
EMBL AK315378 AL035086 AL049694 AL133260
GenPept BAG37771