InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CENPE

Summary

InnateDB Protein

IDBP-812826.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPE

Protein Name

centromere protein E, 312kDa

Synonyms

CENP-E; KIF10; PPP1R61;

Species

Homo sapiens

Ensembl Protein

ENSP00000483542

InnateDB Gene

IDBG-32488 (CENPE)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	24 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003777	microtubule motor activity
GO:0004871	signal transducer activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0008017	microtubule binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007018	microtubule-based movement
GO:0007165	signal transduction
GO:0008152	metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR001752 Kinesin, motor domain
IPR013822 Signal recognition particle, SRP54 subunit, helical bundle
IPR015988 STAT transcription factor, coiled coil
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00225
PF02881

PRINTS

PR00380

PIRSF

SMART

SM00129
SM00963

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt