InnateDB Protein
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IDBP-81293.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MINPP1
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Protein Name
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multiple inositol-polyphosphate phosphatase 1
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Synonyms
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HIPER1; MINPP2; MIPP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361062
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InnateDB Gene
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IDBG-81289 (MINPP1)
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Protein Structure
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Function |
Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). {ECO:0000269PubMed:18413611}.
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Subcellular Localization |
Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.
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Disease Associations |
Note=Defects in MINPP1 may be involved in follicular thyroid tumors development.
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Tissue Specificity |
Widely expressed with highest levels in kidney, liver and placenta. {ECO:0000269PubMed:9923613}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003993
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acid phosphatase activity
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GO:0008969
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phosphohistidine phosphatase activity
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GO:0034417
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bisphosphoglycerate 3-phosphatase activity
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GO:0052826
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inositol hexakisphosphate 2-phosphatase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000560
Histidine phosphatase superfamily, clade-2
IPR029033
Histidine phosphatase superfamily
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PFAM |
PF00328
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UNW1
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PhosphoSite |
PhosphoSite-Q9UNW1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9562
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UniGene |
Hs.121260
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RefSeq |
NP_001171588
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HUGO |
HGNC:7102
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OMIM |
605391
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CCDS |
CCDS53551
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HPRD |
05652
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IMGT |
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EMBL |
AB209819
AF046914
AF084943
AF084944
AK309176
AL050356
AL138767
AL355334
AY358938
BC032504
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GenPept |
AAD02437
AAD09751
AAD09752
AAH32504
AAQ89297
BAD93056
CAB43673
CAH73422
CAH73423
CAI16029
CAI16030
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