Version 5.4
Homo sapiens Protein: TSHZ2
Summary
InnateDB Protein IDBP-81436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSHZ2
Protein Name teashirt zinc finger homeobox 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360552
InnateDB Gene IDBG-81434 (TSHZ2)
Protein Structure
UniProt Annotation
Function Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease. {ECO:0000269PubMed:19343227}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0010468 regulation of gene expression
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR007087 Zinc finger, C2H2
IPR009057 Homeodomain-like
IPR015880 Zinc finger, C2H2-like
PFAM PF00046
PF00096
PRINTS
PIRSF
SMART SM00389
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRE2
PhosphoSite PhosphoSite-Q9NRE2
TrEMBL S4R3C8
UniProt Splice Variant
Entrez Gene 128553
UniGene Hs.649877
RefSeq NP_775756
HUGO HGNC:13010
OMIM 614118
CCDS CCDS33490
HPRD 10730
IMGT
EMBL AF230201 AK091206 AK302570 AL050316 AL109930 AL121902 AL354772 AL354993 AL391097 BX276189 BX640770
GenPept AAF76850 BAC03610 BAH13747 CAE45871 CAI95385 CAI95730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca