InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF217

Summary

InnateDB Protein

IDBP-81508.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF217

Protein Name

zinc finger protein 217

Synonyms

ZABC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000304308

InnateDB Gene

IDBG-81504 (ZNF217)

Protein Structure

UniProt Annotation

Function

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269PubMed:16203743, ECO:0000269PubMed:16940172, ECO:0000269PubMed:17259635, ECO:0000269PubMed:18625718}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated