Version 5.4
Homo sapiens Protein: FKBP15
Summary
InnateDB Protein IDBP-81521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP15
Protein Name FK506 binding protein 15, 133kDa
Synonyms FKBP133; KIAA0674; PPP1R76;
Species Homo sapiens
Ensembl Protein ENSP00000238256
InnateDB Gene IDBG-81519 (FKBP15)
Protein Structure
UniProt Annotation
Function May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement. {ECO:0000250, ECO:0000269PubMed:19121306}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}. Early endosome {ECO:0000269PubMed:19121306}. Note=Present in axons and neuronal growth cones. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0006457 protein folding
GO:0006897 endocytosis
GO:0010923 negative regulation of phosphatase activity
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0005884 actin filament
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
Protein Structure and Domains
PDB ID
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR016137 Regulator of G protein signalling superfamily
PFAM PF00254
PRINTS
PIRSF
SMART SM00315
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T1M5
PhosphoSite PhosphoSite-Q5T1M5
TrEMBL B4DZS8
UniProt Splice Variant
Entrez Gene 23307
UniGene Hs.703312
RefSeq NP_056073
HUGO HGNC:23397
OMIM
CCDS CCDS48007
HPRD
IMGT
EMBL AB014574 AK303074 AL449105 AL449305 BC009609 BC077732
GenPept AAH09609 AAH77732 BAA31649 BAG64190 CAI10963 CAI10964 CAI95402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca