InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSC22D3

Summary

InnateDB Protein

IDBP-81593.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSC22D3

Protein Name

TSC22 domain family, member 3

Synonyms

DIP; DSIPI; GILZ; hDIP; TSC-22R;

Species

Homo sapiens

Ensembl Protein

ENSP00000361458

InnateDB Gene

IDBG-81583 (TSC22D3)

Protein Structure

UniProt Annotation

Function

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down- regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells. {ECO:0000269PubMed:11313722, ECO:0000269PubMed:12393603}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	31 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043426	MRF binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006970	response to osmotic stress
GO:0007589	body fluid secretion
GO:0034220	ion transmembrane transport
GO:0045087	innate immune response (InnateDB)
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0055085	transmembrane transport
GO:0070236	negative regulation of activation-induced cell death of T cells