InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TUSC3

Summary

InnateDB Protein

IDBP-8162.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUSC3

Protein Name

tumor suppressor candidate 3

Synonyms

D8S1992; M33; MRT22; MRT7; N33; OST3A;

Species

Homo sapiens

Ensembl Protein

ENSP00000371450

InnateDB Gene

IDBG-8156 (TUSC3)

Protein Structure

UniProt Annotation

Function

Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase. {ECO:0000269PubMed:19717468}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Mental retardation, autosomal recessive 7 (MRT7) [MIM:611093]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:18452889, ECO:0000269PubMed:18455129}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas. {ECO:0000269PubMed:12887896}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0015095	magnesium ion transmembrane transporter activity

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0015693	magnesium ion transport
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045454	cell redox homeostasis
GO:0050890	cognition

Cellular Component

GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0008250	oligosaccharyltransferase complex