InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HLA-DMA

Summary

InnateDB Protein

IDBP-81654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DMA

Protein Name

major histocompatibility complex, class II, DM alpha

Synonyms

D6S222E; DMA; HLADM; RING6;

Species

Homo sapiens

Ensembl Protein

ENSP00000363976

InnateDB Gene

IDBG-81652 (HLA-DMA)

Protein Structure

UniProt Annotation

Function

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269PubMed:16547258, ECO:0000269PubMed:8849454, ECO:0000269PubMed:9768757}.

Subcellular Localization

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0002503	peptide antigen assembly with MHC class II protein complex
GO:0006461	protein complex assembly
GO:0006955	immune response
GO:0015031	protein transport
GO:0016064	immunoglobulin mediated immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045059	positive thymic T cell selection
GO:0045582	positive regulation of T cell differentiation
GO:0048839	inner ear development
GO:0050778	positive regulation of immune response
GO:0051085	chaperone mediated protein folding requiring cofactor

Cellular Component

GO:0005622	intracellular
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0042613	MHC class II protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001003 MHC class II, alpha chain, N-terminal
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein

PFAM

PF00993
PF07654

PRINTS

PIRSF

SMART

SM00920
SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28067