Version 5.4
Homo sapiens Protein: DOK5
Summary
InnateDB Protein IDBP-81694.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK5
Protein Name docking protein 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262593
InnateDB Gene IDBG-81690 (DOK5)
Protein Structure
UniProt Annotation
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Subcellular Localization
Disease Associations
Tissue Specificity Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269PubMed:12595900, ECO:0000269PubMed:12730241}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005158 insulin receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P104
PhosphoSite PhosphoSite-Q9P104
TrEMBL
UniProt Splice Variant
Entrez Gene 55816
UniGene Hs.656582
RefSeq NP_060901
HUGO HGNC:16173
OMIM 608334
CCDS CCDS13446
HPRD 16317
IMGT
EMBL AF132732 AF466368 AL050069 AL118501 AL162292 BC008992
GenPept AAF66443 AAH08992 AAL74194 CAB43255 CAI16465 CAI19415 CAI19416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca