InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CH25H

Summary

InnateDB Protein

IDBP-81835.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CH25H

Protein Name

cholesterol 25-hydroxylase

Synonyms

C25H;

Species

Homo sapiens

Ensembl Protein

ENSP00000360918

InnateDB Gene

IDBG-81833 (CH25H)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000269PubMed:9852097}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001567	cholesterol 25-hydroxylase activity
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006699	bile acid biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0008206	bile acid metabolic process
GO:0016126	sterol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process