InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHPF

Summary

InnateDB Protein

IDBP-81875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHPF

Protein Name

chondroitin polymerizing factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243776

InnateDB Gene

IDBG-81871 (CHPF)

Protein Structure

UniProt Annotation

Function

Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress. {ECO:0000269PubMed:12761225}.

Subcellular Localization

Isoform 1: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, cytosol.Isoform 3: Cytoplasm, cytosol. Mitochondrion.Isoform 2: Mitochondrion matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells. {ECO:0000269PubMed:12716890, ECO:0000269PubMed:12761225, ECO:0000269PubMed:22082830}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008376	acetylgalactosaminyltransferase activity
GO:0046872	metal ion binding
GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process