InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFIT3

Summary

InnateDB Protein

IDBP-81923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFIT3

Protein Name

interferon-induced protein with tetratricopeptide repeats 3

Synonyms

CIG-49; GARG-49; IFI60; IFIT4; IRG2; ISG60; P60; RIG-G;

Species

Homo sapiens

Ensembl Protein

ENSP00000360876

InnateDB Gene

IDBG-81919 (IFIT3)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269PubMed:17050680, ECO:0000269PubMed:20686046, ECO:0000269PubMed:21190939, ECO:0000269PubMed:21642987, ECO:0000269PubMed:21813773}.

Subcellular Localization

Cytoplasm. Mitochondrion.

Disease Associations

Tissue Specificity

Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver. {ECO:0000269PubMed:18706081}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.

Experimentally validated
Total	67 [view]
Protein-Protein	65 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0035457	cellular response to interferon-alpha
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway