Version 5.4
Homo sapiens Protein: SGPP2
Summary
InnateDB Protein IDBP-82204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGPP2
Protein Name sphingosine-1-phosphate phosphatase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315137
InnateDB Gene IDBG-82202 (SGPP2)
Protein Structure
UniProt Annotation
Function Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. {ECO:0000269PubMed:12411432, ECO:0000269PubMed:17113265}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12411432}; Multi-pass membrane protein {ECO:0000269PubMed:12411432}.
Disease Associations
Tissue Specificity Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. {ECO:0000269PubMed:12411432}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0042392 sphingosine-1-phosphate phosphatase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006670 sphingosine metabolic process
GO:0016311 dephosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IWX5
PhosphoSite PhosphoSite-
TrEMBL Q53QF5
UniProt Splice Variant
Entrez Gene 130367
UniGene Hs.591604
RefSeq NP_689599
HUGO HGNC:19953
OMIM 612827
CCDS CCDS2453
HPRD 18048
IMGT
EMBL AC097461 AC112718 AF542512 AK096323 AK314322 BC106904 BC106905 BC134342
GenPept AAI06905 AAI06906 AAI34343 AAN28731 AAX88957 AAY24195 BAC04762 BAG36970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca