InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTAF1

Summary

InnateDB Protein

IDBP-82406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTAF1

Protein Name

BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)

Synonyms

MOT1; TAF(II)170; TAF172; TAFII170;

Species

Homo sapiens

Ensembl Protein

ENSP00000265990

InnateDB Gene

IDBG-82404 (BTAF1)

Protein Structure

UniProt Annotation

Function

Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004386	helicase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008152	metabolic process
GO:0035562	negative regulation of chromatin binding
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR000357 HEAT
IPR001650 Helicase, C-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016024 Armadillo-type fold
IPR022707 Domain of unknown function DUF3535
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF02985
PF00271
PF12054

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14981