InnateDB Protein
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IDBP-8248.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCNDBP1
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Protein Name
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cyclin D-type binding-protein 1
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Synonyms
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DIP1; GCIP; HHM;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000300213
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InnateDB Gene
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IDBG-8246 (CCNDBP1)
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Protein Structure
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Function |
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. {ECO:0000269PubMed:10801854}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. {ECO:0000269PubMed:10801854, ECO:0000269PubMed:10854051, ECO:0000269PubMed:10915743, ECO:0000269PubMed:15887118, ECO:0000269PubMed:17131381}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
28
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95273
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PhosphoSite |
PhosphoSite-O95273
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TrEMBL |
B4DHB5
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UniProt Splice Variant |
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Entrez Gene |
23582
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UniGene |
Hs.723766
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RefSeq |
NP_036274
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HUGO |
HGNC:1587
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OMIM |
607089
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CCDS |
CCDS10092
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HPRD |
06156
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IMGT |
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EMBL |
AC068724
AF082569
AF087852
AF113535
AF132034
AF246144
AK075146
AK075296
AK128849
AK290665
AK290707
AK295017
BC009689
CH471125
CR450331
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GenPept |
AAD11777
AAF14872
AAF67182
AAF77613
AAH09689
AAP97163
BAC11433
BAC11530
BAC87645
BAF83354
BAF83396
BAG58076
CAG29327
EAW92588
EAW92590
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