InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAPPA

Summary

InnateDB Protein

IDBP-82512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPPA

Protein Name

pregnancy-associated plasma protein A, pappalysin 1

Synonyms

ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000330658

InnateDB Gene

IDBG-82510 (PAPPA)

Protein Structure

UniProt Annotation

Function

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269PubMed:10077652, ECO:0000269PubMed:10913121, ECO:0000269PubMed:11522292}.

Subcellular Localization

Secreted {ECO:0000269PubMed:10077652}.

Disease Associations

Tissue Specificity

High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. {ECO:0000269PubMed:10077652, ECO:0000269PubMed:10491647, ECO:0000269PubMed:7508748, ECO:0000269PubMed:7526035}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007565	female pregnancy
GO:0030154	cell differentiation
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000800 Notch domain
IPR003961 Fibronectin, type III
IPR006558 LamG-like jellyroll fold
IPR008754 Peptidase M43, pregnancy-associated plasma-A
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR011936 Myxococcus cysteine-rich repeat

PFAM

PF00084
PF00066
PF00041
PF01108
PF05572
PF13948

PRINTS

PR01452

PIRSF

SMART

SM00032
SM00004
SM00060
SM00560

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt