Version 5.4
Homo sapiens Protein: EXOC6
Summary
InnateDB Protein IDBP-82584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOC6
Protein Name exocyst complex component 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000260762
InnateDB Gene IDBG-82578 (EXOC6)
Protein Structure
UniProt Annotation
Function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006904 vesicle docking involved in exocytosis
GO:0015031 protein transport
GO:0030218 erythrocyte differentiation
GO:0044267 cellular protein metabolic process
GO:0061024 membrane organization
Cellular Component
GO:0000145 exocyst
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR007225 Exocyst complex subunit Sec15-like
PFAM PF04091
PRINTS
PIRSF PIRSF025007
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAG9
PhosphoSite PhosphoSite-Q8TAG9
TrEMBL Q9NTA6
UniProt Splice Variant
Entrez Gene 54536
UniGene Hs.655657
RefSeq NP_061926
HUGO HGNC:23196
OMIM 609672
CCDS CCDS7424
HPRD 10216
IMGT
EMBL AF220217 AL137438 AL157705 AL358613 AL392103 AL590080 BC028395 CH471066
GenPept AAF37262 AAH28395 CAB70736 CAH72805 CAH74087 CAI40847 EAW50083

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca