Version 5.4
Homo sapiens Protein: SPHKAP
Summary
InnateDB Protein IDBP-82702.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPHKAP
Protein Name SPHK1 interactor, AKAP domain containing
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000339886
InnateDB Gene IDBG-82700 (SPHKAP)
Protein Structure
UniProt Annotation
Function Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. {ECO:0000269PubMed:12080051, ECO:0000269PubMed:20394097}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12080051, ECO:0000269PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm.
Disease Associations
Tissue Specificity Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. {ECO:0000269PubMed:12080051, ECO:0000269PubMed:20394097}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051018 protein kinase A binding
Biological Process
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR018292 A-kinase anchor 110kDa, C-terminal
PFAM PF05716
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2M3C7
PhosphoSite PhosphoSite-Q2M3C7
TrEMBL
UniProt Splice Variant
Entrez Gene 80309
UniGene Hs.609616
RefSeq NP_085126
HUGO HGNC:30619
OMIM 611646
CCDS CCDS33389
HPRD 18052
IMGT
EMBL AB051465 BC104954 BC104956 CR749297 CR749494
GenPept AAI04955 AAI04957 BAB21769 CAH18152 CAH18317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca