InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNER

Summary

InnateDB Protein

IDBP-82733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNER

Protein Name

delta/notch-like EGF repeat containing

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000345229

InnateDB Gene

IDBG-82731 (DNER)

Protein Structure

UniProt Annotation

Function

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, spinal cord and adrenal gland. {ECO:0000269PubMed:11997712}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030276	clathrin binding

Biological Process

GO:0001764	neuron migration
GO:0006897	endocytosis
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007416	synapse assembly
GO:0007417	central nervous system development
GO:0010001	glial cell differentiation
GO:0048741	skeletal muscle fiber development