InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPC5

Summary

InnateDB Protein

IDBP-82799.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPC5

Protein Name

transient receptor potential cation channel, subfamily C, member 5

Synonyms

PPP1R159; TRP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000262839

InnateDB Gene

IDBG-82797 (TRPC5)

Protein Structure

UniProt Annotation

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250, ECO:0000269PubMed:16284075}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16284075}; Multi-pass membrane protein {ECO:0000269PubMed:16284075}.

Disease Associations

Tissue Specificity

Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. {ECO:0000269PubMed:9687496}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0034704	calcium channel complex

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005461 Transient receptor potential channel, canonical 5
IPR005821 Ion transport domain
IPR013555 Transient receptor ion channel domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF08344
PF11929
PF12796

PRINTS

PR01415
PR01097
PR01646

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt