InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMOT

Summary

InnateDB Protein

IDBP-82886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMOT

Protein Name

angiomotin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361027

InnateDB Gene

IDBG-82880 (AMOT)

Protein Structure

UniProt Annotation

Function

Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. {ECO:0000269PubMed:11257124, ECO:0000269PubMed:16678097}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:16043488}. Note=Localized on the cell surface. May act as a transmembrane protein.

Disease Associations

Tissue Specificity

Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. {ECO:0000269PubMed:11257124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.

Experimentally validated
Total	95 [view]
Protein-Protein	94 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0043532	angiostatin binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0003365	establishment of cell polarity involved in ameboidal cell migration
GO:0006935	chemotaxis
GO:0007043	cell-cell junction assembly
GO:0016525	negative regulation of angiogenesis
GO:0030036	actin cytoskeleton organization
GO:0030334	regulation of cell migration
GO:0034260	negative regulation of GTPase activity
GO:0034613	cellular protein localization
GO:0035329	hippo signaling
GO:0040019	positive regulation of embryonic development
GO:0042074	cell migration involved in gastrulation
GO:0043116	negative regulation of vascular permeability
GO:0043534	blood vessel endothelial cell migration
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045793	positive regulation of cell size
GO:0048514	blood vessel morphogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051496	positive regulation of stress fiber assembly

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005923	tight junction
GO:0008180	COP9 signalosome
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle