InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITM2C

Summary

InnateDB Protein

IDBP-82985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITM2C

Protein Name

integral membrane protein 2C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322730

InnateDB Gene

IDBG-82983 (ITM2C)

Protein Structure

UniProt Annotation

Function

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269PubMed:19114711}.

Disease Associations

Tissue Specificity

High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. {ECO:0000269PubMed:11290423, ECO:0000269PubMed:15606899}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0010977	negative regulation of neuron projection development
GO:0030182	neuron differentiation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome