InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGTR2

Summary

InnateDB Protein

IDBP-83077.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGTR2

Protein Name

angiotensin II receptor, type 2

Synonyms

AT2; ATGR2; MRX88;

Species

Homo sapiens

Ensembl Protein

ENSP00000360973

InnateDB Gene

IDBG-83075 (AGTR2)

Protein Structure

UniProt Annotation

Function

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. {ECO:0000269PubMed:15123706}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. {ECO:0000269PubMed:12089445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017046	peptide hormone binding
GO:0048019	receptor antagonist activity

Biological Process

GO:0001822	kidney development
GO:0001974	blood vessel remodeling
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0002035	brain renin-angiotensin system
GO:0006883	cellular sodium ion homeostasis
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007263	nitric oxide mediated signal transduction
GO:0007420	brain development
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0010243	response to organonitrogen compound
GO:0010459	negative regulation of heart rate
GO:0010700	negative regulation of norepinephrine secretion
GO:0021695	cerebellar cortex development
GO:0030308	negative regulation of cell growth
GO:0032304	negative regulation of icosanoid secretion
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035556	intracellular signal transduction
GO:0035566	regulation of metanephros size
GO:0035640	exploration behavior
GO:0035815	positive regulation of renal sodium excretion
GO:0035932	aldosterone secretion
GO:0038166	angiotensin-activated signaling pathway
GO:0042416	dopamine biosynthetic process
GO:0042990	regulation of transcription factor import into nucleus
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045909	positive regulation of vasodilation
GO:0048147	negative regulation of fibroblast proliferation
GO:0050715	positive regulation of cytokine secretion
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060993	kidney morphogenesis
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0071549	cellular response to dexamethasone stimulus
GO:0072300	positive regulation of metanephric glomerulus development
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:1900116	extracellular negative regulation of signal transduction
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000147 Angiotensin II receptor type 2
IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00636
PR00241
PR00237
PR00657
PR00425

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50052