InnateDB Protein
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IDBP-83158.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COPS7B
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Protein Name
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COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000272995
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InnateDB Gene
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IDBG-83156 (COPS7B)
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Protein Structure
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Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
40
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000717
Proteasome component (PCI) domain
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PFAM |
PF01399
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PRINTS |
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PIRSF |
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SMART |
SM00088
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H9Q2
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PhosphoSite |
PhosphoSite-Q9H9Q2
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TrEMBL |
J3KQV6
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UniProt Splice Variant |
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Entrez Gene |
64708
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UniGene |
Hs.734190
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RefSeq |
NP_073567
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HUGO |
HGNC:16760
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OMIM |
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CCDS |
CCDS2488
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HPRD |
09889
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IMGT |
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EMBL |
AC073476
AK022674
AK024273
BC010739
BC091493
CH471063
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GenPept |
AAH10739
AAH91493
AAY24152
BAB14170
BAB14868
EAW70979
EAW70980
EAW70981
EAW70982
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