Version 5.4
Homo sapiens Protein: CTSZ
Summary
InnateDB Protein IDBP-83300.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSZ
Protein Name cathepsin Z
Synonyms CTSX;
Species Homo sapiens
Ensembl Protein ENSP00000217131
InnateDB Gene IDBG-83296 (CTSZ)
Protein Structure
UniProt Annotation
Function Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:10653163}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0002003 angiotensin maturation
GO:0006508 proteolysis
GO:0044267 cellular protein metabolic process
GO:0060441 epithelial tube branching involved in lung morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
PFAM PF00112
PRINTS PR00705
PIRSF
SMART SM00645
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBR2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1522
UniGene Hs.252549
RefSeq NP_001327
HUGO HGNC:2547
OMIM 603169
CCDS CCDS13474
HPRD 04410
IMGT
EMBL AF009923 AF032906 AF073890 AF136273 AF136274 AF136275 AF136276 AK314931 AL109840 BC042168 CH471077
GenPept AAC39839 AAC61477 AAC63141 AAF13145 AAF13148 AAH42168 BAG37437 CAC09370 EAW75448

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca