Version 5.4
Homo sapiens Protein: PDLIM1
Summary
InnateDB Protein IDBP-83351.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDLIM1
Protein Name PDZ and LIM domain 1
Synonyms CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112;
Species Homo sapiens
Ensembl Protein ENSP00000360305
InnateDB Gene IDBG-83349 (PDLIM1)
Protein Structure
UniProt Annotation
Function Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with the actin stress fibers. {ECO:0000250}.
Disease Associations
Tissue Specificity Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006355 regulation of transcription, DNA-templated
GO:0006979 response to oxidative stress
Cellular Component
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR001781 Zinc finger, LIM-type
IPR006643 ZASP
PFAM PF00595
PF13180
PF00412
PRINTS
PIRSF
SMART SM00228
SM00132
SM00735
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00151
PhosphoSite PhosphoSite-O00151
TrEMBL V9HW92
UniProt Splice Variant
Entrez Gene 9124
UniGene
RefSeq NP_066272
HUGO HGNC:2067
OMIM 605900
CCDS CCDS7441
HPRD 09326
IMGT
EMBL AJ310549 AK314792 AL157834 AL160288 AY923052 BC000915 BC018755 CH471066 FJ224331 U90878
GenPept AAC05580 AAH00915 AAH18755 AAW82438 ACI46023 BAG37323 CAC32846 CAH70720 CAH72341 EAW50009

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca