InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF12

Summary

InnateDB Protein

IDBP-8337.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF12

Protein Name

zinc finger protein 12

Synonyms

GIOT-3; HZF11; KOX3; ZNF325;

Species

Homo sapiens

Ensembl Protein

ENSP00000344745

InnateDB Gene

IDBG-8335 (ZNF12)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity. {ECO:0000269PubMed:16806083}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16806083}.

Disease Associations

Tissue Specificity

Widely expressed in various adult tissues and embryonic developmental stages (isoform 3). {ECO:0000269PubMed:16806083}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated