Version 5.4
Homo sapiens Protein: OTOP1
Summary
InnateDB Protein IDBP-8345.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTOP1
Protein Name otopetrin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296358
InnateDB Gene IDBG-8343 (OTOP1)
Protein Structure
UniProt Annotation
Function Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein. Secreted, extracellular space. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0009590 detection of gravity
GO:0031214 biomineral tissue development
GO:0042472 inner ear morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004878 Otopetrin
PFAM PF03189
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7RTM1
PhosphoSite PhosphoSite-Q7RTM1
TrEMBL
UniProt Splice Variant
Entrez Gene 133060
UniGene Hs.534544
RefSeq NP_819056
HUGO HGNC:19656
OMIM 607806
CCDS CCDS3372
HPRD 07421
IMGT
EMBL BC130430 BC130432 BK000653 BK000654
GenPept AAI30431 AAI30433 DAA00901 DAA00902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca