InnateDB Protein
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IDBP-83480.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPS10
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Protein Name
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ribosomal protein S10
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Synonyms
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DBA9; S10;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000347271
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InnateDB Gene
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IDBG-83478 (RPS10)
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Protein Structure
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Function |
Component of the 40S ribosomal subunit.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20159986}. Nucleus, nucleolus {ECO:0000269PubMed:20159986}. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus.
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Disease Associations |
Diamond-Blackfan anemia 9 (DBA9) [MIM:613308]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269PubMed:20116044}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
123
[view]
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Protein-Protein |
121
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005326
Plectin/S10, N-terminal
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PFAM |
PF03501
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P46783
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PhosphoSite |
PhosphoSite-P46783
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6204
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UniGene |
Hs.731577
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RefSeq |
NP_001191020
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HUGO |
HGNC:10383
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OMIM |
603632
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CCDS |
CCDS4792
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HPRD |
04697
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IMGT |
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EMBL |
AB007151
AK311797
AL157372
BC001032
BC001955
BC005012
BC070235
BC071946
BC073799
CH471081
U14972
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GenPept |
AAA85660
AAH01032
AAH01955
AAH05012
AAH70235
AAH71946
AAH73799
BAA25817
BAG34740
EAX03784
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