Version 5.4
Homo sapiens Protein: UGT1A5
Summary
InnateDB Protein IDBP-83562.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT1A5
Protein Name UDP glucuronosyltransferase 1 family, polypeptide A5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362513
InnateDB Gene IDBG-407464 (UGT1A5)
Protein Structure
UniProt Annotation
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.
Subcellular Localization Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus. {ECO:0000269PubMed:18004212}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008152 metabolic process
GO:0030259 lipid glycosylation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
IPR007235 Glycosyl transferase, family 28, C-terminal
PFAM PF00201
PF04101
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35504
PhosphoSite PhosphoSite-P35504
TrEMBL Q5QTE5
UniProt Splice Variant
Entrez Gene 54579
UniGene Hs.643992
RefSeq NP_061951
HUGO HGNC:12537
OMIM 606430
CCDS CCDS33404
HPRD 07335
IMGT
EMBL AB568100 AC006985 AC114812 AF297093 AF404263 AY435140 CH471063 DQ383514 M84122 M84123 M84124 M84129
GenPept AAA61247 AAA61250 AAG30421 AAQ03151 AAR95641 ABD42927 BAK32965 EAW71059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca