InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNRPC

Summary

InnateDB Protein

IDBP-83692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPC

Protein Name

small nuclear ribonucleoprotein polypeptide C

Synonyms

U1C; Yhc1;

Species

Homo sapiens

Ensembl Protein

ENSP00000244520

InnateDB Gene

IDBG-83690 (SNRPC)

Protein Structure

UniProt Annotation

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000269PubMed:1826349, ECO:0000269PubMed:2136774, ECO:0000269PubMed:8798632}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	69 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003727	single-stranded RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0000395	mRNA 5'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome

Cellular Component

GO:0000243	commitment complex
GO:0005634	nucleus
GO:0005685	U1 snRNP
GO:0015030	Cajal body
GO:0071004	U2-type prespliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000690 Zinc finger, C2H2-type matrin
IPR003604 Zinc finger, U1-type
IPR013085 Zinc finger, U1-C type
IPR017340 U1 small nuclear ribonucleoprotein C

PFAM

PF06220

PRINTS

PIRSF

PIRSF037969

SMART

SM00451

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt