InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MNAT1

Summary

InnateDB Protein

IDBP-8370.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MNAT1

Protein Name

menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)

Synonyms

CAP35; MAT1; RNF66; TFB3;

Species

Homo sapiens

Ensembl Protein

ENSP00000261245

InnateDB Gene

IDBG-8368 (MNAT1)

Protein Structure

UniProt Annotation

Function

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269PubMed:10024882}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.

Experimentally validated
Total	67 [view]
Protein-Protein	66 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0008270	zinc ion binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006461	protein complex assembly
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007512	adult heart development
GO:0008283	cell proliferation
GO:0010467	gene expression
GO:0016032	viral process
GO:0021591	ventricular system development
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050434	positive regulation of viral transcription
GO:0051592	response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005675	holo TFIIH complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR003903 Ubiquitin interacting motif
IPR004575 Cdk-activating kinase assembly factor MAT1/Tfb3
IPR015877 Cdk-activating kinase assembly factor MAT1, centre

PFAM

PF13639
PF14634
PF02809
PF06391

PRINTS

PIRSF

PIRSF003338

SMART

SM00184
SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt