InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFA8

Summary

InnateDB Protein

IDBP-83720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA8

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa

Synonyms

CI-19KD; CI-PGIV; PGIV;

Species

Homo sapiens

Ensembl Protein

ENSP00000362873

InnateDB Gene

IDBG-83718 (NDUFA8)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269PubMed:21310150}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0032403	protein complex binding

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0005758	mitochondrial intermembrane space