InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANKS1A

Summary

InnateDB Protein

IDBP-83769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANKS1A

Protein Name

ankyrin repeat and sterile alpha motif domain containing 1A

Synonyms

ANKS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000353518

InnateDB Gene

IDBG-83767 (ANKS1A)

Protein Structure

UniProt Annotation

Function

Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cell projection {ECO:0000250}. Note=Cytoplasmic before and after growth factor treatment.

Disease Associations

Tissue Specificity

Widely expressed (at protein level).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0006929	substrate-dependent cell migration
GO:0016322	neuron remodeling
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR006020 PTB/PI domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM