InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLL2

Summary

InnateDB Protein

IDBP-83779.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLL2

Protein Name

tolloid-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000350630

InnateDB Gene

IDBG-83775 (TLL2)

Protein Structure

UniProt Annotation

Function

Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007275	multicellular organismal development
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001506 Peptidase M12A, astacin
IPR001881 EGF-like calcium-binding domain
IPR006026 Peptidase, metallopeptidase
IPR015446 Bone morphogenetic protein 1/tolloid-like protein

PFAM

PF00008
PF00431
PF01400
PF07645

PRINTS

PR00480

PIRSF

PIRSF001199

SMART

SM00181
SM00042
SM00179
SM00235

TIGRFAMs

Post-translational Modifications

Modification

Cross-References