Version 5.4
Homo sapiens Protein: NKRF
Summary
InnateDB Protein IDBP-83831.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKRF
Protein Name NFKB repressing factor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360582
InnateDB Gene IDBG-83827 (NKRF)
Protein Structure
UniProt Annotation
Function Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. {ECO:0000269PubMed:12381793}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849}.
Disease Associations
Tissue Specificity Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 29 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR000467 G-patch domain
IPR001374 Single-stranded nucleic acid binding R3H
IPR014720 Double-stranded RNA-binding domain
PFAM PF01585
PF01424
PF00035
PRINTS
PIRSF
SMART SM00443
SM00393
SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15226
PhosphoSite PhosphoSite-O15226
TrEMBL A3F769
UniProt Splice Variant
Entrez Gene 55922
UniGene Hs.437084
RefSeq NP_001166959
HUGO HGNC:19374
OMIM 300440
CCDS CCDS35375
HPRD 02341
IMGT
EMBL AC004913 AJ011812 AL539002 AY208891 BC040379 BC047878 CH471161 EF165092 EF165094 EF216689 Y07707
GenPept AAH40379 AAH47878 AAP43025 ABM55377 ABM55379 ABN11235 CAA68976 CAB56459 EAW89859 EAW89860

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca