InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPARD

Summary

InnateDB Protein

IDBP-83942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARD

Protein Name

peroxisome proliferator-activated receptor delta

Synonyms

FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB;

Species

Homo sapiens

Ensembl Protein

ENSP00000310928

InnateDB Gene

IDBG-83938 (PPARD)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. {ECO:0000269PubMed:1333051, ECO:0000269PubMed:15604518}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous with maximal levels in placenta and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	47 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005504	fatty acid binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0043565	sequence-specific DNA binding
GO:0051059	NF-kappaB binding
GO:0070539	linoleic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0006006	glucose metabolic process
GO:0006029	proteoglycan metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006776	vitamin A metabolic process
GO:0007507	heart development
GO:0007566	embryo implantation
GO:0008203	cholesterol metabolic process
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008366	axon ensheathment
GO:0008654	phospholipid biosynthetic process
GO:0009062	fatty acid catabolic process
GO:0009299	mRNA transcription
GO:0009749	response to glucose
GO:0010033	response to organic substance
GO:0010467	gene expression
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823	response to activity
GO:0014912	negative regulation of smooth muscle cell migration
GO:0015758	glucose transport
GO:0015908	fatty acid transport
GO:0019395	fatty acid oxidation
GO:0030154	cell differentiation
GO:0030308	negative regulation of cell growth
GO:0030522	intracellular receptor signaling pathway
GO:0031589	cell-substrate adhesion
GO:0032024	positive regulation of insulin secretion
GO:0032966	negative regulation of collagen biosynthetic process
GO:0033189	response to vitamin A
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0042640	anagen
GO:0043066	negative regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043616	keratinocyte proliferation
GO:0045598	regulation of fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045684	positive regulation of epidermis development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045909	positive regulation of vasodilation
GO:0046697	decidualization
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0051546	keratinocyte migration
GO:0060612	adipose tissue development
GO:0071456	cellular response to hypoxia
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003075 Peroxisome proliferator-activated receptor, beta
IPR003076 Peroxisome proliferator-activated receptor, alpha
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01288
PR01290
PR01289

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt