InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPP2

Summary

InnateDB Protein

IDBP-83953.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPP2

Protein Name

secreted phosphoprotein 2, 24kDa

Synonyms

SPP-24; SPP24;

Species

Homo sapiens

Ensembl Protein

ENSP00000168148

InnateDB Gene

IDBG-83947 (SPP2)

Protein Structure

UniProt Annotation

Function

Could coordinate an aspect of bone turnover. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Detected in liver and plasma. {ECO:0000269PubMed:15062857}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004869	cysteine-type endopeptidase inhibitor activity

Biological Process

GO:0001501	skeletal system development
GO:0006461	protein complex assembly
GO:0010951	negative regulation of endopeptidase activity
GO:0046849	bone remodeling

Cellular Component

GO:0005576	extracellular region
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000010 Proteinase inhibitor I25, cystatin
IPR010892 Secreted phosphoprotein 24

PFAM

PF00031
PF07448

PRINTS

PIRSF

SMART

SM00043

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13103

PhosphoSite

PhosphoSite-Q13103

TrEMBL

C9J6K0

UniProt Splice Variant

Entrez Gene

6694

UniGene

Hs.444488

RefSeq

NP_008875

HUGO

HGNC:11256

OMIM

602637

CCDS

CCDS2511

HPRD

04029

IMGT

EMBL

AC006037 AJ272265 AJ308099 BC069401 BC106705 BC112438 CH471063 U20530

GenPept

AAA87905 AAH69401 AAI06706 AAI12439 AAX93090 CAB75571 CAC87050 EAW71070