InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TEAD3

Summary

InnateDB Protein

IDBP-84108.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TEAD3

Protein Name

TEA domain family member 3

Synonyms

DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5;

Species

Homo sapiens

Ensembl Protein

ENSP00000345772

InnateDB Gene

IDBG-84102 (TEAD3)

Protein Structure

UniProt Annotation

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269PubMed:18579750, ECO:0000269PubMed:19324877}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Preferentially expressed in the placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007565	female pregnancy
GO:0010467	gene expression
GO:0035329	hippo signaling
GO:0045944	positive regulation of transcription from RNA polymerase II promoter