InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOC2L

Summary

InnateDB Protein

IDBP-84178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOC2L

Protein Name

nucleolar complex associated 2 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317992

InnateDB Gene

IDBG-84176 (NOC2L)

Protein Structure

UniProt Annotation

Function

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269PubMed:16322561, ECO:0000269PubMed:20123734, ECO:0000269PubMed:20959462}.

Subcellular Localization

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin- D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0031491	nucleosome binding
GO:0042393	histone binding
GO:0044822	poly(A) RNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002903	negative regulation of B cell apoptotic process
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0031497	chromatin assembly
GO:0032066	nucleolus to nucleoplasm transport
GO:0034644	cellular response to UV
GO:0035067	negative regulation of histone acetylation
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway