InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCL

Summary

InnateDB Protein

IDBP-84184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCL

Protein Name

phosducin-like

Synonyms

PhLP;

Species

Homo sapiens

Ensembl Protein

ENSP00000259467

InnateDB Gene

IDBG-84182 (PDCL)

Protein Structure

UniProt Annotation

Function

Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0032403	protein complex binding

Biological Process

GO:0006457	protein folding
GO:0007165	signal transduction
GO:0007601	visual perception
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035556	intracellular signal transduction
GO:0061084	negative regulation of protein refolding
GO:1902605	heterotrimeric G-protein complex assembly