Homo sapiens Protein: HES4
Summary
InnateDB Protein IDBP-84294.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HES4
Protein Name hairy and enhancer of split 4 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000304595
InnateDB Gene IDBG-84292 (HES4)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0008134 transcription factor binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003650 Orange
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR018352 Orange subgroup
PFAM PF07527
PF00010
PRINTS
PIRSF
SMART SM00353
SM00511
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCC6
PhosphoSite PhosphoSite-Q9HCC6
TrEMBL
UniProt Splice Variant
Entrez Gene 57801
UniGene
RefSeq NP_066993
HUGO HGNC:24149
OMIM 608060
CCDS CCDS5
HPRD 16273
IMGT
EMBL AB048791 AL645608 BC012351
GenPept AAH12351 BAB13510 CAI15572