InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMP2

Summary

InnateDB Protein

IDBP-84403.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMP2

Protein Name

lysosomal-associated membrane protein 2

Synonyms

CD107b; LAMP-2; LAMPB; LGP110;

Species

Homo sapiens

Ensembl Protein

ENSP00000200639

InnateDB Gene

IDBG-84399 (LAMP2)

Protein Structure

UniProt Annotation

Function

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. {ECO:0000269PubMed:8407947}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255PROSITE- ProRule:PRU00740, ECO:0000269PubMed:17897319}. Endosome membrane {ECO:0000269PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255PROSITE-ProRule:PRU00740, ECO:0000269PubMed:17897319}. Lysosome membrane {ECO:0000255PROSITE-ProRule:PRU00740, ECO:0000269PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255PROSITE-ProRule:PRU00740, ECO:0000269PubMed:17897319}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Disease Associations

Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. {ECO:0000269PubMed:15673802, ECO:0000269PubMed:15907287}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019899	enzyme binding

Biological Process

GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0050821	protein stabilization

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031088	platelet dense granule membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome