Version 5.4
Homo sapiens Protein: RPS19BP1
Summary
InnateDB Protein IDBP-8446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS19BP1
Protein Name ribosomal protein S19 binding protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333948
InnateDB Gene IDBG-8444 (RPS19BP1)
Protein Structure
UniProt Annotation
Function Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. {ECO:0000269PubMed:17964266}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:17964266}.
Disease Associations
Tissue Specificity Widely expressed (at protein level). {ECO:0000269PubMed:17964266}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR023262 Active regulator of SIRT1
PFAM
PRINTS PR02029
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86WX3
PhosphoSite PhosphoSite-Q86WX3
TrEMBL A0A024R1T1
UniProt Splice Variant
Entrez Gene 91582
UniGene Hs.664693
RefSeq NP_919307
HUGO HGNC:28749
OMIM 610225
CCDS CCDS13997
HPRD 14674
IMGT
EMBL AL022312 BC037573 BC047711 CH471095 CR456443
GenPept AAH37573 AAH47711 CAG30329 CAQ08288 EAW60343 EAW60344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca